At the time of this interview, Greg Siegle is a leading researcher and Director of the Program in Cognitive and Affective Neuroscience as well as a professor of Psychiatry and Translational Sciences at the University of Pittsburgh School of Medicine. His work spans psychiatry, neuroscience, and, intriguingly, horror studies, where he examines the intersection of fear, emotion, and psychological resilience. Our discussion explores his research on how fear functions in the brain, the potential for horror as a therapeutic tool, and the role of immersive technologies like virtual reality (VR) in mental health treatments.